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- Title
Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease.
- Authors
Cardozo, Ludmila F M F; Alvarenga, Livia A; Ribeiro, Marcia; Dai, Lu; Shiels, Paul G; Stenvinkel, Peter; Lindholm, Bengt; Mafra, Denise
- Abstract
Sulforaphane (SFN) is a sulfur-containing isothiocyanate found in cruciferous vegetables (Brassicaceae) and a well-known activator of nuclear factor-erythroid 2-related factor 2 (Nrf2), considered a master regulator of cellular antioxidant responses. Patients with chronic diseases, such as diabetes, cardiovascular disease, cancer, and chronic kidney disease (CKD) present with high levels of oxidative stress and a massive inflammatory burden associated with diminished Nrf2 and elevated nuclear transcription factor-κB-κB expression. Because it is a common constituent of dietary vegetables, the salutogenic properties of sulforaphane, especially it's antioxidative and anti-inflammatory properties, have been explored as a nutritional intervention in a range of diseases of ageing, though data on CKD remain scarce. In this brief review, the effects of SFN as a senotherapeutic agent are described and a rationale is provided for studies that aim to explore the potential benefits of SFN-rich foods in patients with CKD.
- Subjects
CHRONIC kidney failure; BROCCOLI; GUT microbiome; GLYCOSIDES; MITOCHONDRIA; OXIDATIVE stress; BRASSICACEAE; MOLECULAR structure
- Publication
Nutrition Reviews, 2021, Vol 79, Issue 11, p1204
- ISSN
0029-6643
- Publication type
Article
- DOI
10.1093/nutrit/nuaa129