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- Title
Impact of westernization on fibroblast growth factor 23 levels among individuals of African ancestry.
- Authors
Eckberg, Karl; Kramer, Holly; Wolf, Myles; Durazo-Arvizu, Ramon; Tayo, Bamidele; Luke, Amy; Cooper, Richard
- Abstract
Introduction. The Western diet is associated with high consumption of processed foods preserved with phosphate. Higher dietary phosphate consumption stimulates production of fibroblast growth factor 23 (FGF23), which heightens risk for cardiovascular disease and mortality. We hypothesized that adults living in a more westernized society have higher levels of FGF23 due to increased phosphate consumption as measured by urinary phosphate excretion. Methods. We measured plasma C-terminal FGF23 levels and urinary phosphate and creatinine levels in timed urine collections among 100 African adults living in the rural area of Igbo-Ora, Nigeria (52 women, 48 men), and 100 African Americans (32 women, 68 men) living in Maywood, IL, an significantly higher in Maywood versus Igbo-Ora (810.6 ± 309.0 versus 347.5 ± 153.1 mg; P < 0.001) and FGF23 levels correlated significantly with total urinary phosphate excretion (r = 0.62; P < 0.001) and urinary phosphate-to-creatinine ratios (r = 0.50; P < 0.001). Conclusions. Living in a more westernized society may be associated with greater net phosphate absorption, as reflected by higher urinary phosphate excretion, and higher FGF23 levels.
- Subjects
FOOD consumption; WESTERN diet; WESTERNIZATION; FIBROBLAST growth factors; AFRICANS; PHYSIOLOGICAL effects of phosphates; FOOD preservation; DISEASES
- Publication
Nephrology Dialysis Transplantation, 2015, Vol 30, Issue 4, p630
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfu342