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- Title
Copeptin, a surrogate marker for vasopressin, is associated with kidney function decline in subjects with autosomal dominant polycystic kidney disease.
- Authors
Boertien, Wendy E.; Meijer, Esther; Zittema, Debbie; van Dijk, Marjan A.; Rabelink, Ton J.; Breuning, Martijn H.; Struck, Joachim; Bakker, Stephan J.L.; Peters, Dorien J.M.; de Jong, Paul E.; Gansevoort, Ron T.
- Abstract
The observational study by Boertin et al makes a valuable contribution to the research field of prevention and control of polycystic kidney disease, supports the assumption that copeptin is associated with disease severity in ADPKD and may have useful implications for the design of future clinical trials […]Background Experimental studies have suggested that vasopressin plays a detrimental role in autosomal dominant polycystic kidney disease (ADPKD). It is, however, unknown whether endogenous vasopressin concentration is associated with kidney function decline in subjects with ADPKD. Methods We measured plasma copeptin (a marker of vasopressin) in 79 ADPKD subjects with renal function assessed during short-term follow-up by inulin clearance measured glomerular filtration rate (mGFR) and during long-term follow-up by Modification of Diet in Renal Disease (MDRD) equation estimated GFR (eGFR). Results In these subjects (43% male, age 36.8 ± 10.1 years, GFR 96.8 ± 18.2 mL/min/1.73 m2), median copeptin concentration at baseline was 2.71 [interquartile ranges (IQR) 1.63–5.46] pmol/L. Baseline copeptin concentration was inversely associated both with change in mGFR during follow-up for 3.3 (3.1–3.5) years, (R = −0.300, P = 0.01), as well as with change in eGFR during follow-up for 11.2 (4.5–14.3) years, (R = −0.302, P < 0.01). These associations were independent of age, gender and baseline GFR. Nine subjects started renal replacement therapy during follow-up of which eight had at baseline a copeptin concentration above the median in this population. Conclusion In ADPKD subjects, a higher copeptin concentration is associated with kidney function decline during follow-up, suggesting that copeptin may be a new marker to predict kidney outcome in ADPKD.
- Subjects
BIOMARKERS; VASOPRESSIN; POLYCYSTIC kidney disease; CLINICAL trials; CYSTIC kidney disease
- Publication
Nephrology Dialysis Transplantation, 2012, Vol 27, Issue 11, p4131
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfs070