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- Title
Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance.
- Authors
Ge, Rongbin; Wang, Zongwei; Cheng, Liang
- Abstract
Prostate cancer is characterized by a high degree of heterogeneity, which poses a major challenge to precision therapy and drug development. In this review, we discuss how nongenetic factors contribute to heterogeneity of prostate cancer. We also discuss tumor heterogeneity and phenotypic switching related to anticancer therapies. Lastly, we summarize the challenges targeting the tumor environments, and emphasize that continued exploration of tumor heterogeneity is needed in order to offer a personalized therapy for advanced prostate cancer patients.
- Subjects
PROSTATE cancer; CANCER invasiveness; TUMOR microenvironment; PROSTATE cancer patients; HETEROGENEITY; CANCER patients
- Publication
NPJ Precision Oncology, 2022, Vol 6, Issue 1, p1
- ISSN
2397-768X
- Publication type
Article
- DOI
10.1038/s41698-022-00272-w