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- Title
Deep Sequencing of Acute Myeloid Leukemia Reveals Driver Mutations and New Targets.
- Authors
Brower, Vicki
- Abstract
The article reports on the result of a study showing that patients with acute myeloid leukemia whose mutations persisted a month after starting treatment were three times more likely to relapse and die as those who cleared the mutations. The study is designed to determine whether mutations in the genome detected at the beginning of treatment were associated with outcomes. Whole-genome sequencing has been used for the study.
- Subjects
ACUTE myeloid leukemia treatment; ANTINEOPLASTIC agents; DRUG therapy; DNA; GENETIC mutation; OXIDOREDUCTASES; PROGNOSIS; ACUTE myeloid leukemia; SEQUENCE analysis; CHEMICAL inhibitors; PHARMACODYNAMICS
- Publication
JNCI: Journal of the National Cancer Institute, 2016, Vol 108, Issue 2, p3
- ISSN
0027-8874
- Publication type
journal article
- DOI
10.1093/jnci/djw018