We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A 4-Channel Optogenetic Stimulation, 16-Channel Recording Neuromodulation System with Real-Time Micro-LED Detection Function.
- Authors
Xia, Yu; Zheng, Ruihan; Wang, Liyang; Zhang, Anguo; Li, Dongming; Wu, Yufei; Gao, Yueming; Xu, Yanyan; Zhang, Baijun; Li, Hungchun; Mak, Peng Un; Vai, Mang I.; Pun, Sio Hang
- Abstract
Neuromodulation techniques are essential for exploring brain science and supporting treatments for neurological disorders. Compared to electrical neuromodulation, optogenetic neuromodulation offers advantages in cell type specificity and spatial precision. However, existing optogenetic neuromodulation systems have limited functionality (unable to simultaneously possess functions including optogenetic stimulation, recording, and micro-LED (micro-Light-Emitting Diode) status monitoring) and will restrict normal biological activities due to their large size. To this end, this paper presents an optogenetic neuromodulation system, including a specified neuromodulation IC (Integrated Circuit) and a customized optrode. The ASIC (Application Specific Integrated Circuit) includes a 16-channel neural signal recording module, a 4-channel optogenetic neurostimulator module, and a 4-channel micro-LED detection module. The micro-LED detection module monitors the micro-LED's long-term status in real time and provides the direct output of its working status for convenient user access. The neuromodulation ASIC was fabricated in the TSMC 65 nm process, and an in situ normal saline experiment was conducted to test the neuromodulation system's function.
- Subjects
TAIWAN Semiconductor Manufacturing Co. Ltd.; APPLICATION-specific integrated circuits; NEUROMODULATION; OPTICAL communications; LIGHT emitting diodes; NEURAL stimulation
- Publication
Electronics (2079-9292), 2023, Vol 12, Issue 23, p4783
- ISSN
2079-9292
- Publication type
Article
- DOI
10.3390/electronics12234783