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- Title
Expression and Correlation of TCR γ δ/γ 2 in Peripheral Blood and Tumor Tissue of Human Colorectal Cancer.
- Authors
LI Wen-liang; WANG Zhi-qiang; WEN Zheng-qi; YIN Liang; YANG Jun; ZHU Zhu; ZHANG Hong-bin
- Abstract
Objective To investigate the expression and correlation of TCR α β, TCR γ δ and TCR δ 2 in peripheral blood and tumor tissue of colorectal cancer patients, and provide evidence for immunotherapy based on γ δ T cell. Methods The expression of TCR α β, TCR γ δ and TCR δ 2 in peripheral blood, normal intestinal mucosa, paracancerous and carcinoma tissue of colorectal cancer patient were detected with flow cytometry. The correlation between the expression of TCR δ 2 in peripheral blood and TCR γ δ, TCR δ 2 in tissue was analyzed. Results The expression levels of TCR γ δ, TCR δ 2 in peripheral blood were obviously higher than that of the control group. The expression levels of TCR γ δ, TCR δ 2 in paracancerous and carcinoma tissue were higher than those of the normal intestinal mucosa tissue. With the expression of TCR δ 2 in peripheral blood at a high level the expression of TCR γ δ and TCR δ 2 in paracancerous tissues increased simultaneously, whereas the expression of TCR γ δ and TCR δ 2 declined in carcinoma tissue. Conclusions There are correlation between the level of V δ 2 T cell in peripheral blood and the level of γ δ T cell and V δ 2 T cell in carcinoma tissue of colorectal cancer patient, which may provide theoretical evidence for regional intervention therapy of V δ 2 T cell.
- Subjects
T-cell receptor genes; COLON cancer; IMMUNOTHERAPY; GENE expression; BLOOD; TUMORS
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 12, p54
- ISSN
2095-610X
- Publication type
Article