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- Title
Impact on weight and physical function of intensive medical weight loss in older adults with stage II and III obesity.
- Authors
Ard, Jamy D.; Cook, Miranda; Rushing, Julia; Frain, Annette; Beavers, Kristen; Miller, Gary; Miller, Michael E.; Nicklas, Barb
- Abstract
<bold>Objective: </bold>A 6-month pilot trial compared two strategies for weight loss in older adults with body mass indexes (BMIs) ≥35 kg/m(2) to assess weight loss response, safety, and impact on physical function.<bold>Methods: </bold>Twenty-eight volunteers were randomized to a balanced deficit diet (BDD) (500 kcal/day below estimated energy needs) or an intensive, low-calorie, meal replacement diet (ILCD, 960 kcal/day). Behavioral interventions and physical activity prescriptions were similar for both groups. Primary outcomes were changes in body weight and adverse event frequency; secondary outcomes included measures of physical function and body composition.<bold>Results: </bold>ILCD average weight change was -19.1 ± 2.2 kg or 15.9 ± 4.6% of initial body weight compared with -9.1 ± 2.7 kg or 7.2 ± 1.9% for BDD. ILCD lost more fat mass (-7.7 kg, 95% CI [-11.9 to -3.5]) but had similar loss of lean mass (-1.7 kg, 95% CI [-4.1 to 0.6]) compared with BDD. There were no significant differences in change in physical function or adverse event frequency.<bold>Conclusions: </bold>Compared with a traditional BDD intervention, older adults who have severe obesity treated with intensive medical weight loss had greater weight loss and decreases in fat mass without a higher frequency of adverse events. In the short term, however, this did not translate into greater improvements in physical function.
- Subjects
WEIGHT loss; OLDER people; OBESITY; PHYSICAL activity; DIET; NUTRITIONALLY induced diseases; OBESITY treatment; OBESITY complications; BEHAVIOR therapy; BODY composition; DIET therapy; EXERCISE; REDUCING diets; RESEARCH funding; BODY mass index; MORBID obesity; RANDOMIZED controlled trials; TREATMENT effectiveness; DISEASE complications; THERAPEUTICS
- Publication
Obesity (19307381), 2016, Vol 24, Issue 9, p1861
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.21569