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- Title
Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses.
- Authors
Yu, Wenfeng; Ma, Honghai; Yu, Guocan; Xia, Pinghui; An, Zhou; Yu, Li; Lv, Wang; Ye, Bo; Hu, Jian
- Abstract
The present study aimed to explore the final diagnosis of pulmonary nodules with an initial non-diagnostic result on electromagnetic navigation bronchoscopy (ENB) biopsy and the predictive factors for a non-diagnostic result. A total of 198 nodules from 194 patients that were suspected to be malignant tumors were included in the present study. The initial biopsy pathology results were divided into two groups: The diagnostic group and the non-diagnostic group. The diagnostic group was defined as a successful initial biopsy to obtain a diagnosis, including malignant and benign diagnoses. The non-diagnostic group was defined as a non-specific benign diagnosis, normal lung tissue or an unsuccessful biopsy. Among the 198 nodules, 139 (70.2%) were in the diagnostic group and 59 (29.8%) were in the non-diagnostic group. Predictive factors for a non-diagnostic biopsy included nodule size ≤1.5 cm [odds ratio (OR), 2.05; 95% confidence interval (CI), 1.03-4.09], non-solid nodules (OR, 2.71; 95% CI, 1.33-5.64) and nodules in the left lung (OR, 2.50; 95% CI, 1.27-4.92). Of the 59 non-diagnostic biopsies, 46 were finally confirmed to be malignant by surgery. Notably, non-diagnostic biopsies with non-solid nodules (OR, 7.64; 95% CI, 3.11-18.76) were more likely to be malignant. In conclusion, the predictive factors for a non-diagnostic biopsy were nodule size ≤1.5 cm and non-solid nodules. It was not rare for patients to finally be diagnosed with a malignancy in the non-diagnostic group. Therefore, care should be taken when the results of an ENB are non-diagnostic to prevent misdiagnosis.
- Subjects
BIOPSY; BRONCHOSCOPY; DIAGNOSIS; PULMONARY nodules; SOLITARY pulmonary nodule; ODDS ratio
- Publication
Oncology Letters, 2023, Vol 25, Issue 4, pN.PAG
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2023.13751