We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Immune-Enhancing Effects of Red Platycodon grandiflorus Root Extract via p38 MAPK-Mediated NF-κB Activation.
- Authors
Park, Eun-Jung; Lee, You-Suk; Kim, Sung Min; Jung, Ah Jin; Yoo, Jeong-Hyun; Lee, Sung-Hyen; Jeong, Hyun Cheol; Lee, Hae-Jeung
- Abstract
Platycodongrandiflorus (PG) root extract has been widely used as an oriental herbal medicine. Red PG root extract (RPGE), which is made by steaming and drying PG several times, contains more saponin than raw (white) PG. Although RPGE has been known to have anti-inflammatory activity, the effects of RPGE on the immune-enhancing response remain unclear. In this study, we aimed to investigate the immune-enhancing effects of RPGE and its mechanism in macrophage cells and splenocytes. Our results revealed that cell proliferation of both macrophages and splenocytes correlate positively with the concentration of RPGE. Moreover, RPGE treatment increased the phagocytic activity of macrophage cells, as well as nitric oxide and cytokines production. Furthermore, RPGE induced phosphorylation of the p38 mitogen-activated protein kinase, which contributed to nuclear factor-kappa B activation. Thus, our findings suggest that RPGE may be a potential functional food for improving immune function.
- Subjects
NF-kappa B; MITOGEN-activated protein kinases; ASIAN medicine; EXTRACTS
- Publication
Applied Sciences (2076-3417), 2020, Vol 10, Issue 16, p5457
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app10165457