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- Title
Effect of dicarboxylic acids on normal human melanocytes in dispersed tissue culture.
- Authors
Breathnach, A. S.; Martin, B.; Porro, M. Nazzaro; Passi, S.; Mann, P.; Cooper, J.; Morpurgo, G.
- Abstract
Since dicarboxylic acids are competitive inhibitors of tyrosinase, and effective in treatment of hyperpigmentary disorders, such as chloasma and lentigo maligna, probably due to a cytotoxic effect on abnormal melanocytes, it is of interest to examine their effect on normal melanocytes in tissue culture. Azelaic or dodecandioic acids were added (150–200 μg/ml) to dispersed cultures of epidermal cells, and melanocytcs were examined by electron microscopy after 7, 10, 15, 20 and 30 days. Apart from a stimulation of melanogencsis, the presence of dicarboxylic acids in the culture medium caused no detectable damage to melanocytcs, nor did they prevent growth of a second generation of cells.
- Subjects
CARBOXYLIC acids; MELANOCYTES; EPITHELIAL cells; TISSUE culture; PHENOL oxidase; PIGMENTATION disorders
- Publication
British Journal of Dermatology, 1979, Vol 101, Issue 6, p641
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1979.tb05642.x