We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective.
- Authors
Agarwal, Khushbu; Manza, Peter; Chapman, Marquis; Nawal, Nafisa; Biesecker, Erin; McPherson, Katherine; Dennis, Evan; Johnson, Allison; Volkow, Nora D.; Joseph, Paule V.
- Abstract
Chronic exposure to addictive drugs in substance use disorders and stressors in mood disorders render the brain more vulnerable to inflammation. Inflammation in the brain, or neuroinflammation, is characterized by gliosis, microglial activation, and sustained release of cytokines, chemokines, and pro-inflammatory factors compromising the permeability of the blood-brain barrier. There is increased curiosity in understanding how substance misuse and/or repeated stress exposure affect inflammation and contribute to abnormal neuronal activity, altered neuroplasticity, and impaired cognitive control, which eventually promote compulsive drug-use behaviors and worsen mood disorders. This review will emphasize human imaging studies to explore the link between brain function and peripheral markers of inflammation in substance use disorders and mood disorders.
- Subjects
AFFECTIVE disorders; SUBSTANCE-induced disorders; SUBSTANCE abuse; COMPULSIVE behavior; ENCEPHALITIS; NEONATAL abstinence syndrome
- Publication
Frontiers in Psychiatry, 2022, Vol 13, p1
- ISSN
1664-0640
- Publication type
Article
- DOI
10.3389/fpsyt.2022.863734