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- Title
Increased body mass index is associated with sarcopenia and related outcomes.
- Authors
Hashim, Nurul Nabilah Akmal; Mat, Sumaiyah; Myint, Phyo Kyaw; Kioh, Sheng Hui; Delibegovic, Mirela; Chin, Ai‐Vyrn; Kamaruzzaman, Shahrul Bahyah; Hairi, Noran Naqiah; Khoo, Selina; Tan, Maw Pin
- Abstract
Several cardiometabolic factors such as diabetes, hypertension and dyslipidemia which are prevalent in older adults with increased body mass index (BMI) may play an important role in sarcopenia development.[[2], [7]] Excess fat mass interrupts the blood glucose pathway and triggers insulin resistance which may then further enhance the development of sarcopenia. Hospitalization rates over 5 years among individuals with BMI >= 30 kg/m SP 2 sp compared to those with normal BMI following adjustments in Model 2 and remained significant with slight attenuation after differences in diabetes status were accounted for [RR (95%CI): 1.90 (1.11-3.28), Model 3]. The direct effect of BMI categories on the risk of all outcomes (Y1, Y2, Y3) was significant for BMI >= 30 kg/m SP 2 sp but not BMI < 18.5 or BMI: 25-29.9 kg/m SP 2 sp compared to those the BMI: 18.5-25 kg/m SP 2 sp group, suggesting the potential mediating role of FBG (Figure 2A-C).
- Subjects
BODY mass index; SARCOPENIA; ADIPOSE tissue diseases; SOMATOMEDIN C; METABOLIC disorders
- Publication
European Journal of Clinical Investigation, 2023, Vol 53, Issue 2, p1
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.13874