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- Title
Limitations to body length/serum creatinine ratio as an estimate of glomerular filtration in children.
- Authors
Seikaly, Mouin G.; Browne, Richard; Bajaj, Geeta; Arant Jr., Billy S.
- Abstract
The ability of the Schwartz formula (C[sub SCH] ) to estimate glomerular filtration rate (GFR) accurately was investigated in children with renal disease.[sup 125] Iodine-iothalamate clearance (C[sub IO] ) was used as the reference standard for measuring GFR. Data from 176 C[sub IO] studies performed on 133 children (aged between 1 and 18 years) were compared with the simultaneous estimation of GFR by C[sub SCH] . The overestimation of GFR by C[sub SCH] was inversely proportional to the level of renal function. When C[sub IO] was >90 ml/min per 1.73 m[sup 2] , C[sub SCH] overestimated GFR by only 0.1%±3%, but when C[sub IO] was ≤15 ml/min per 1.73 m[sup 2] , C[sub SCH] overestimated GFR by 164%±42%. When renal function is normal or mildly reduced (GFR >50 ml/min per 1.73 m[sup 2] ), C[sub SCH] overestimated C[sub IO] by only 10.3±3.0%, compared with 90.3±14.5% when renal function was moderately to severely curtailed (GFR ≤50 ml/min per 1.73 m[sup 2] ). We conclude that C[sub SCH] is valid in predicting GFR only in children with normal renal function and mild insufficiency.
- Subjects
GLOMERULAR filtration rate; KIDNEY glomerulus
- Publication
Pediatric Nephrology, 1996, Vol 10, Issue 6, p709
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s004670050195