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- Title
Low molecular weight antioxidants and their role in skin ageing.
- Authors
Podda, M.; Grundmann-Kollmann, M.
- Abstract
There is increasing evidence that reactive oxygen species play a pivotal role in the process of ageing. The skin, as the outermost barrier of the body, is exposed to various exogenous sources of oxidative stress, in particular UV-irradiation. These are believed to be responsible for the extrinsic type of skin ageing, termed photo-ageing. It therefore seems reasonable to try to increase levels of protective low molecular weight antioxidants through a diet rich in fruits and vegetables or by direct topical application. Indeed, various in vitro and animal studies have proved that low molecular weight antioxidants, especially vitamins C and E, ascorbate and tocopherol, as well as lipoic acid, exert protective effects against oxidative stress. However, controlled long-term studies on the efficacy of low molecular weight antioxidants in the prevention or treatment of skin ageing in humans are still lacking.
- Subjects
AGING prevention; ANTIOXIDANTS; IRRADIATION; PHYSIOLOGY
- Publication
Clinical & Experimental Dermatology, 2001, Vol 26, Issue 7, p578
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1046/j.1365-2230.2001.00902.x