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- Title
Hypofractionated Postoperative Radiotherapy in Prostate Cancer with Ialuril Soft Gels<sup>®</sup>: Toxicity and Efficacy Analysis on a Retrospective Series of 305 Patients.
- Authors
Nicosia, Luca; Vitale, Claudio; Cuccia, Francesco; Figlia, Vanessa; Giaj-Levra, Niccolò; Mazzola, Rosario; Ricchetti, Francesco; Rigo, Michele; Ruggieri, Ruggero; Cavalleri, Stefano; Alongi, Filippo
- Abstract
Aim: To evaluate the impact of Ialuril soft Gels® (HA) in reducing acute genito-urinary (GU) toxicity in patients treated with adjuvant or salvage radiotherapy for a prostate cancer relapse. Material and Methods: The data of 305 patients were retrospectively collected. One hundred and five patients underwent adjuvant radiotherapy (aRT), while 200 a salvage treatment (sRT). GU toxicity was evaluated according to CTCAE v5.0. Every patient received RT combined with HA. Results: Grade 1– 2 GU toxicity during RT was represented by: urgency (36%), dysuria (23%), increased urinary frequency (12.1%), and urinary retention (11.8%). Nevertheless, the majority of symptoms were present at the baseline. Grade 3 severe toxicity was represented by 10 (3.2%) cases of incontinence and 3 (1%) cases of urgency. The incidence of any-grade RT-related GU toxicity was significantly higher in the aRT group than the salvage group (esRT + sRT) (83.8% versus 64.5%). When comparing the incidence of any-grade RT-related GU toxicity in the aRT, esRT, and sRT groups we observed a significant correlation favoring sRT, over esRT, and aRT. Conclusion: Postoperative hypofractionated radiotherapy is safe and not correlated with increase of unexpected toxicity when administered with oral hyaluronic acid. A prospective study is necessary to confirm these results.
- Subjects
PROSTATE cancer; RADIOTHERAPY; CANCER radiotherapy; CANCER relapse; RETROSPECTIVE studies; HYALURONIC acid
- Publication
Cancer Management & Research, 2022, Vol 14, p2839
- ISSN
1179-1322
- Publication type
Article
- DOI
10.2147/CMAR.S357814