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- Title
Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression.
- Authors
Marwitz, Sebastian; Heinbockel, Lena; Scheufele, Swetlana; Nitschkowski, Dörte; Kugler, Christian; Perner, Sven; Reck, Martin; Ammerpohl, Ole; Goldmann, Torsten
- Abstract
Hwang et al. recently showed that VGF substantially contributes to the resistance of human lung cancer cells towards epidermal growth factor receptor kinase inhibitors. This was further linked to enhanced epithelial-mesenchymal transition. Here, we demonstrate that VGF is epigenetically modified in non-small cell lung cancer tissues compared to corresponding tumor-free lung tissues from the same donors by using methylome bead chip analyses. These epigenetic modifications trigger an increased transcription of the VGF gene within the tumors, which then leads to an increased expression of the protein, facilitating epithelial-mesenchymal transition and the resistance to kinase inhibitors. These results should be taken into account in the design of novel therapeutic and diagnostic approaches.
- Subjects
NON-small-cell lung carcinoma; EPIGENETICS; CANCER cells
- Publication
Clinical Epigenetics, 2017, Vol 9, p1
- ISSN
1868-7075
- Publication type
Article
- DOI
10.1186/s13148-017-0423-6