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- Title
Are There Different Forms of Life in the Antineutrophil Cytoplasmic Antibody Universe?
- Authors
Hoffman, Gary S.; Langford, Carol A.
- Abstract
The article presents information about the different forms of life in the antineutrophil cytoplasmic antibody universe. The causes of most forms of noninfectious vasculitis are unknown, despite being labeled as autoimmune. For some autoimmune diseases, autoantibodies and their target antigens provide some information about pathogenesis and disease phenotypes. Antibody directed against certain neutrophil cytoplasmic proteins is present in several forms of vasculitis. Wegener granulomatosis is characterized by granulomatous inflammation of the upper and lower airways, glomerulonephritis, and vasculitis of small- to medium sized vessels. Antineutrophil cytoplasmic antibodies directed against proteinase 3 are present in about 90% of patients with severe Wegener granulomatosis and in about 65% of patients with milder disease
- Subjects
NEUTROPHILS; GRANULOMATOSIS with polyangiitis; VASCULITIS; PHENOTYPES; GLOMERULONEPHRITIS; VASCULAR diseases
- Publication
Annals of Internal Medicine, 2005, Vol 143, Issue 9, p683
- ISSN
0003-4819
- Publication type
Editorial
- DOI
10.7326/0003-4819-143-9-200511010-00012