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- Title
Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa.
- Authors
Grinspoon, Steven; Thomas, Elizabeth; Pitts, Sarah; Gross, Erin; Mickley, Diane; Miller, Karen; Herzog, David; Klibanski, Anne; Grinspoon, S; Thomas, E; Pitts, S; Gross, E; Mickley, D; Miller, K; Herzog, D; Klibanski, A
- Abstract
<bold>Background: </bold>Anorexia nervosa is highly prevalent among young women.<bold>Objective: </bold>To determine prevalence and predictive factors for regional bone loss.<bold>Design: </bold>Prospective cohort analysis.<bold>Setting: </bold>University hospital.<bold>Patients: </bold>130 women with anorexia nervosa.<bold>Measurements: </bold>Dual-energy x-ray absorptiometry.<bold>Results: </bold>The prevalence of osteopenia (-1.0 SD >/= T-score > -2.5 SD) and osteoporosis (T-score </= -2.5 SD) was 50% and 13% for the anterior-posterior spine, 57% and 24% for the lateral spine, and 47% and 16% for the total hip, respectively. Bone mineral density (BMD) was reduced by at least 1.0 SD at one or more skeletal sites in 92% of patients and by at least 2.5 SD in 38% of patients. Weight was the most consistent predictor of BMD at all skeletal sites. Twenty-three percent of patients were current estrogen users, and 58% were previous estrogen users. Bone mineral density did not differ by history of estrogen use at any site.<bold>Conclusions: </bold>Bone mineral density is reduced at several skeletal sites in most women with anorexia nervosa. Weight, but not estrogen use, is a significant predictor of BMD in this population at all skeletal sites.
- Subjects
DISEASES in women; OSTEOPENIA; ANOREXIA nervosa; ANOREXIA nervosa complications; AGE distribution; COMPARATIVE studies; HORMONE therapy; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; MENARCHE; OSTEOPOROSIS; REGRESSION analysis; RESEARCH; EVALUATION research; BONE density; DISEASE prevalence; PHOTON absorptiometry
- Publication
Annals of Internal Medicine, 2000, Vol 133, Issue 10, p790
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-133-10-200011210-00011