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- Title
In vitro and in vivo anti-MRSA activities of nosokomycins.
- Authors
Uchida, Ryuji; Hanaki, Hideaki; Matsui, Hidenori; Hamamoto, Hiroshi; Sekimizu, Kazuhisa; Iwatsuki, Masato; Yong-Pil Kim; Tomoda, Hiroshi
- Abstract
The anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of nosokomycins A to D discovered in the silkworm-MRSA infection screening was investigated. The minimum inhibitory concentration (MIC) values of nosokomycins for authentic MRSA and S. aureus strains were calculated to be 0.06 to 2.0 μg/mL. They also showed potent inhibitory activity against 54 clinically isolated MRSA strains. Furthermore, nosokomycin A proved effective in the mouse-MRSA infection model.
- Subjects
METHICILLIN-resistant staphylococcus aureus; SILKWORMS; INHIBITION (Chemistry); DRUG therapy; PHARMACOLOGY
- Publication
Drug Discoveries & Therapeutics, 2014, Vol 8, Issue 6, p249
- ISSN
1881-7831
- Publication type
Article
- DOI
10.5582/ddt.2014.01050