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- Title
Immunolocalization of α[sub2], α[sub5] and α[sub6] integrin subunits in salivary tissue and adenomas of the parotid gland.
- Authors
Franchi, Alessandro; Santoro, Roberto; Paglierani, Milena; Bondi, Roberto
- Abstract
The localization of the integrin subunits &alpha[SUB2], &alpha[SUB5], &alpha[SUB6] was studied immunohistochemically in samples of normal salivary gland and in a series of 8 pleomorphic adenomas, 5 Warthin's tumors, and 2 basal cell adenomas. In normal salivary tissue, acinar and ductal cells expressed &alpha[SUB2] and &alpha[SUB6] chains at the basal cell pole facing the basement membrane. &alpha[SUB2] also localized at sites of cell-cell contact. No staining of the epithelial component was seen with &alpha[SUB5]. The polarized expression of &alpha[SUB2] an d &alpha[SUB6] subunits was retained in salivary adenomas. These subunits were present at the basal cell pole of solid nests, tubules and ducts of plecomorphic adenomas, as well as of the basal layer of the epithelium of Warthin's tumor, and of the trabecular structures of basal cell adenomas. The &alpha[SUB5] subunit was consistently expressed only by cells embedded in the myxoid or chondroid matrix of pleomorphic adenomas. We conclude that the pattern of a integrin subunit expression in salivary adenomas may be related to the "epithelial" or "mesenchymal" phenotype of the neoplastic cells.
- Subjects
EXTRACELLULAR matrix; IMMUNOHISTOCHEMISTRY; INTEGRINS; SALIVARY glands
- Publication
Journal of Oral Pathology & Medicine, 1994, Vol 23, Issue 10, p457
- ISSN
0904-2512
- Publication type
Article
- DOI
10.1111/j.1600-0714.1994.tb00444.x