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- Title
Hepatoblastoma presenting as precocious puberty: a case report.
- Authors
Marino, Silvia; Caruso, Manuela; Magro, Gaetano; D'Amico, Salvatore; La Spina, Milena; Moscheo, Carla; Russo, Giovanna; Di Cataldo, Andrea
- Abstract
Hepatoblastoma (HB), a primary liver tumor in childhood, is often accompanied by alpha-fetoprotein (AFP) secretion, and sometimes by β-human chorionic gonadotropin hormone (β-hCG) secretion, and this can cause peripheral precocious puberty (PPP). We describe a case of PPP associated with HB. Laboratory tests showed an increase in AFP, β-hCG and testosterone values, and suppression of follicle-stimulating hormone and luteinizing hormone levels. After chemotherapy and surgery, AFP, β-hCG and testosterone levels normalized and signs of virilization did not progress further. The child did not show evidence for tumor recurrence after 16 months of follow-up. New therapeutic approaches and early diagnosis may ensure a better prognosis of virilizing HB, than reported in the past. Assessment of PPP should always take into account the possibility of a tumoral source.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2015, Vol 28, Issue 3/4, p429
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem-2014-0167