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- Title
Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis.
- Authors
Yoshikawa, Fabio S. Y.; Yabe, Rikio; Iwakura, Yoichiro; de Almeida, Sandro R.; Saijo, Shinobu
- Abstract
Dermatophytoses are chronic fungal infections, the main causative agent of which is Trichophyton rubrum (T. rubrum). Despite their high occurrence worldwide, the immunological mechanisms underlying these diseases remain largely unknown. Here, we uncovered the C-type lectin receptors, Dectin-1 and Dectin-2, as key elements in the immune response to T. rubrum infection in a model of deep dermatophytosis. In vitro, we observed that deficiency in Dectin-1 and Dectin-2 severely compromised cytokine production by dendritic cells. In vivo, mice lacking Dectin-1 and/or Dectin-2 showed an inadequate pro-inflammatory cytokine production in response to T. rubrum infection, impairing its resolution. Strikingly, neither adaptive immunity nor IL-17 response were required for fungal clearance, highlighting innate immunity as the main checkpoint in the pathogenesis of T. rubrum infection.
- Subjects
RINGWORM; IMMUNE response; TRICHOPHYTON; INTERLEUKIN-17; DENDRITIC cells
- Publication
Innate Immunity, 2016, Vol 22, Issue 5, p316
- ISSN
1753-4259
- Publication type
Article
- DOI
10.1177/1753425916645392