We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Reversible acute renal failure induced by losartan in a renal transplant recipient.
- Authors
Ostermann, M.; Goldsmith, D. J.; Doyle, T.; Kingswood, J. C.; Sharpstone, P.
- Abstract
A 56-year-old man who received a live-related renal transplant in 1988 was started in 1995 on the selective angiotensin II antagonist losartan (Dupont-Merke) to treat worsening hypertension. Two months later because of pulmonary oedema, loop diuretics were started. Within two weeks, serum creatinine had increased from 245 to 571 mumol/l, and the patient became oliguric. A systolic bruit was noted over the graft. Renal angiography showed a 90% stenosis of the transplant renal artery. Losartan was withdrawn, with prompt improvement in renal function. A successful percutaneous transluminal angioplasty performed a few days later resulted in further improvement in renal function accompanied by a significant diuresis.
- Publication
Postgraduate Medical Journal, 1997, Vol 73, Issue 856, p105
- ISSN
0032-5473
- Publication type
journal article
- DOI
10.1136/pgmj.73.856.105