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- Title
Characterization of Two Highly Homologous Autoantibody-Related VH1 Genes in Humans.
- Authors
Yang, P.-M.; Olee, T.; Carson, D. A.; Chen, P. P.
- Abstract
Previously, we showed that the Humha llr rearranged gene was almost identical to the consensus amino acid sequence of several G6 idiotype-positive rheumatoid factor (RF) heavy chains, and to the VH gene-encoded region of the fetally expressed 51P1 cDNA. The finding led us to suggest that the hallr-corresponding germline gene encodes the heavy chains of many human IgM RFs. We now report the isolation of the proposed germline gene, designated Humhv1051; it is identical to the consensus sequence of the G6 heavy chain V regions. During this experiment, we also isolated unexpectedly an additional VH1 gene, termed Humhv1051K; it differs from hv1051 by one amino acid residue. Importantly, Hv105IK is identical to Humha 113, the rearranged VH1 gene of a natural anti-cardiolipin antibody.
- Subjects
AMINO acids; RHEUMATOID factor; CHRONIC lymphocytic leukemia; ANTIGENS; IMMUNOGLOBULINS; GENES
- Publication
Scandinavian Journal of Immunology, 1993, Vol 37, Issue 4, p504
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1993.tb03326.x