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- Title
Patients with severe obstructive sleep apnea syndrome and elevated high-sensitivity C-reactive protein need priority treatment
- Authors
Lee, Li-Ang; Chen, Ning-Hung; Huang, Chung-Guei; Lin, Shih-Wei; Fang, Tuan-Jen; Li, Hsueh-Yu
- Abstract
Abstract: Objective: To evaluate the clinical factors predicting the significantly elevated high-sensitivity C-reactive protein (hs-CRP) concentrations, defined herein as hs-CRP ≥ 3 mg/L, in adult males with untreated obstructive sleep apnea syndrome (OSAS). Study Design: Cross-sectional study. Setting: Tertiary referral center. Subjects and Methods: Sixty-five consecutive male patients with newly diagnosed OSAS were enrolled to receive complete medical history review, physical examination, in-laboratory overnight polysomnography, and hs-CRP test. The patients had no current or history of cardiovascular disease. The patients had a mean age of 38.2 ± 9.9 years, body mass index (BMI) of 27.4 ± 3.5 kg/m2, and Epworth Sleepiness Scale (ESS) of 11.3 ± 4.6. The serum levels of hs-CRP were assessed using peripheral venous blood samples. Results: Twenty-three percent of the overall patients had significantly elevated serum levels of hs-CRP. The increase of hs-CRP correlated fairly with BMI, apnea-hypopnea index (AHI), tonsil size, and ESS (r = 0.450, 0.398, 0.393, and 0.300, respectively; all P ≤ 0.05) after adjustment for conventional coronary heart disease risk factors. However, only the AHI could predict for significantly elevated hs-CRP after stepwise multiple linear regression (R 2 = 0.251, P < 0.001). Conclusion: Patients in this study with hs-CRP ≥ 3 mg/L were more prevalent in the severe OSAS group. This observation suggests that the severe OSAS patients need to have their cardiovascular statuses evaluated by use of an hs-CRP screening test.
- Subjects
SLEEP apnea syndrome treatment; C-reactive protein; CROSS-sectional method; POLYSOMNOGRAPHY; BODY mass index; CORONARY heart disease risk factors; REGRESSION analysis
- Publication
Otolaryngology-Head & Neck Surgery, 2010, Vol 143, Issue 1, p72
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1016/j.otohns.2010.04.001