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- Title
Expression of p63 and 14-3-3σ in normal and hyperdifferentiated mucosa of the upper aerodigestive tract
- Authors
Sniezek, Joseph C.; Matheny, Keith E.; Burkey, Brian B.; Netterville, James L.; Pietenpol, Jennifer A.
- Abstract
Objective: Our goal was to analyze p63 and 14-3-3σ expression in normal and hyperdifferentiated head and neck mucosa. Study Design: Compare the in vivo expression of p63 and 14-3-3σ by immunohistochemistry in normal mucosa and oral lichen planus, a benign mucosal lesion marked by hyperdifferentiation and apoptosis. Results and Conclusion: p63 is underexpressed and 14-3-3σ is overexpressed in lichen planus on immunohistochemical analysis. Significance: The findings support the hypothesis that p63 plays an antidifferentiation role, whereas 14-3-3σ plays a prodifferentiation role in the upper aerodigestive tract epithelium. Lichen planus is a valuable model for the study of p63, 14-3-3σ, and mucosal differentiation. p63 and 14-3-3σ may be molecular markers for oral lichen planus. (Otolaryngol Head Neck Surg 2002;126:598-601.)
- Subjects
MUCOUS membranes; IMMUNOHISTOCHEMISTRY; LICHEN planus; APOPTOSIS
- Publication
Otolaryngology-Head & Neck Surgery, 2002, Vol 126, Issue 6, p598
- ISSN
0194-5998
- Publication type
journal article
- DOI
10.1067/mhn.2002.125302