We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A comparative study of isolated and metachronous oesophageal squamous cell carcinoma with antecedent upper aerodigestive tract cancer.
- Authors
Lu, Hung-I; Li, Shau-Hsuan; Huang, Wan-Ting; Rau, Kun-Ming; Fang, Fu-Min; Wang, Yu-Ming; Lin, Wei-Che; Tien, Wan-Yu
- Abstract
OBJECTIVES Metachronous oesophageal squamous cell carcinoma (OSCC) has been increasing in long-term survivors of upper aerodigestive tract (UADT) cancers in recent years, but the treatment of such cases is not well established. The aim of this study was to compare the prognosis between patients with metachronous OSCC who had antecedent UADT cancers and patients with isolated OSCC. METHODS From January 1995 to December 2009, we retrospectively compared the data from 84 patients with metachronous OSCC who had antecedent UADT cancers (metachronous group) with the data from 527 patients with isolated OSCC (isolated group) according to their treatment modalities at Kaohsiung Chang Gung Memorial Hospital. RESULTS Overall, the metachronous group had significantly (P = 0.03) worse overall survival than the isolated group. For patients receiving surgery or preoperative chemoradiotherapy followed by surgery, the overall survival rates and incidence of postoperative complications were not significantly different. For patients receiving definite chemoradiotherapy or radiotherapy alone, the metachronous group had significantly (P = 0.02) inferior overall survival compared with the isolated group. CONCLUSIONS Offering a radical approach for the treatment of patients with metachronous OSCC who had antecedent UADT cancers is justifiable, with survival rates similar to those of patients with isolated OSCC.
- Subjects
ESOPHAGUS; SQUAMOUS cell carcinoma; ALIMENTARY canal cancer; CANCER patients; RETROSPECTIVE studies; COMPARATIVE studies
- Publication
European Journal of Cardio-Thoracic Surgery, 2013, Vol 44, Issue 5, p860
- ISSN
1010-7940
- Publication type
Article
- DOI
10.1093/ejcts/ezt112