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- Title
THE INFLUENCE OF THE EPIDERMIS AND OTHER TISSUES ON BLOOD VESSEL GROWTH IN THE HAMSTER CHEEK POUCH.
- Authors
Nishioka, Kiyoshi; Ryan, Terence J.
- Abstract
In order to demonstrate an epidermal influence on blood vessels various tissues from neonatal hamsters, enclosed by Millipore filters, were transplanted into hamster cheek pouch chambers. Epidermis, buccal membrane and lung induced new vessel growth, while heart muscle, dermis and other tissues did not. The new capillaries grew as loops over the Millipore filter to surround the epidermal transplant but never to cover it. They anastomosed with each other and formed a network: similar to that seen in normal human skin. Only incomplete capillary growth was noted around the lung transplant. New capillary growth was prominent at the vascular membrane side around buccal membrane. At least three kinds of epidermal influence on blood vessels were suggested by this experiment: a) stimulation of new vessel growth, b) scaffold formation for the capillaries to climb up over the Millipore filter, and c) barrier formation to prevent vessel invasion into the epidermis.
- Subjects
EPIDERMIS; HAMSTERS; EPITHELIUM; SKIN blood-vessels; MUCOUS membranes; MYOCARDIUM
- Publication
Journal of Investigative Dermatology, 1972, Vol 58, Issue 1, p33
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep13077211