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- Title
Epstein–Barr virus early-antigen antibodies before allogeneic haematopoietic stem cell transplantation as a marker of risk of post-transplant lymphoproliferative disorders.
- Authors
Agbalika, Felix; Larghero, Jerome; Esperou, Helene; Marais, Dominique; Robin, Marie; Foïs, Elena; de Latour, Régis Peffault; Gluckman, Eliane; Rocha, Vanderson; Benbunan, Marc; Soci, Gerard; Marolleau, Jean-Pierre
- Abstract
The occurrence of post-transplant lymphoproliferative disorders (PTLDs) after allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents a clinical problem. Pretransplant Epstein–Barr virus serological status and viral load was determined in 21 recipients and 28 control transplanted patients, with (+) and without (−) PTLD, respectively. Early-antigen immunoglobulin G (EA-IgG) was detected in 12/21 PTLD+ patients, but only 2/28 PTLD− patients ( P = 0·00023, Odds ratio = 17·42). High viral load was detected in peripheral blood mononuclear cells at PTLD diagnosis, independently of deleted LMP1. Detection of EA-IgG in allo-HSCT recipients pretransplantation might be considered as risk factor for PTLD development.
- Subjects
EPSTEIN-Barr virus diseases; LYMPHOPROLIFERATIVE disorders; STEM cells; TRANSPLANTATION of organs, tissues, etc.; IMMUNOGLOBULIN G
- Publication
British Journal of Haematology, 2007, Vol 136, Issue 2, p305
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2006.06420.x