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Prion diseases-close to effective therapy?
- Published in:
- Nature Reviews Drug Discovery, 2004, v. 3, n. 10, p. 874, doi. 10.1038/nrd1525
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- Article
A method for systematically ranking therapeutic drug candidates using multiple uncertain screening criteria.
- Published in:
- 2021
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- Publication type:
- journal article
Selective targeting and protection against toxic amyloid‐beta oligomers by PMN310, a monoclonal antibody rationally designed for greater therapeutic potency in Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.079734
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- Publication type:
- Article
Rational design of a vaccine for Alzheimer's disease using a computationally‐derived conformational epitope to selectively target toxic amyloid‐beta oligomers.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.079769
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- Publication type:
- Article
Distinguishing between amyloid‐beta‐directed antibodies: Ability of PMN310 to target toxic oligomers despite competing species.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.067371
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- Publication type:
- Article
Selective targeting of intracellular, misfolded, pathogenic TDP‐43 with rationally designed intrabodies.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.055269
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- Publication type:
- Article
Conformational epitopes exposed on misfolded toxic forms of amyloid‐beta, tau and alpha‐synuclein directly contribute to their seeding activity.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.055254
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- Publication type:
- Article
Epitope prediction for oligomer‐selective antibodies in tau and Aβ: Molecular and cell biology/tau.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045757
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- Publication type:
- Article
Rationally designed antibodies selective for pathogenic tau aggregates: Nonhuman: Preclinical immunotherapeutic studies.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045461
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- Publication type:
- Article
Targeting of misfolded, pathogenic TDP‐43 with rationally designed antibodies: Nonhuman/Target identification and validation studies: Proteostasis.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045221
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- Publication type:
- Article
Cerebrovascular amyloid angiopathy in bioengineered vessels is reduced by high‐density lipoprotein particles enriched in apolipoprotein E: Development of new models and analysis methods/amyloid/Abeta.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043473
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- Publication type:
- Article
O5‐06‐01: SELECTIVE TARGETING OF AMYLOID‐BETA OLIGOMER SPECIES BY PMN310, A MONOCLONAL ANTIBODY RATIONALLY DESIGNED FOR GREATER THERAPEUTIC POTENCY IN ALZHEIMER'S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1628, doi. 10.1016/j.jalz.2019.06.4864
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- Publication type:
- Article
P4‐163: THE PATHOLOGICAL INTERACTOME OF TDP‐43 INCLUDES HUMAN WILDTYPE SOD1.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1336, doi. 10.1016/j.jalz.2019.06.3825
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- Publication type:
- Article
O3‐01‐02: CHIMERA REPETITIVE MILD TRAUMATIC BRAIN INJURY INDUCES CHRONIC BEHAVIORAL AND NEUROPATHOLOGICAL PHENOTYPES IN WILD‐TYPE AND APP/PS1 MICE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P875, doi. 10.1016/j.jalz.2019.06.4625
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- Publication type:
- Article
P2‐048: HUMANIZED PMN310 SHOWS ENHANCED THERAPEUTIC POTENTIAL BY BINDING TOXIC LOW MOLECULAR WEIGHT Aβ OLIGOMERS WHILE AVOIDING ARIA‐RELATED BINDING TO Aβ DEPOSITS IN AD PATIENT BRAINS.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P685, doi. 10.1016/j.jalz.2018.06.732
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- Publication type:
- Article
Anticholinesterases in Post-Poliomyelitis Syndrome<sup>a</sup>.
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- Annals of the New York Academy of Sciences, 1995, v. 753, n. 1, p. 285, doi. 10.1111/j.1749-6632.1995.tb27554.x
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- Publication type:
- Article
Antibody Titer to the Poliovirus in Blood and Cerebrospinal Fluid of Patients with Post-Polio Syndrome.
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- Annals of the New York Academy of Sciences, 1995, v. 753, n. 1, p. 201, doi. 10.1111/j.1749-6632.1995.tb27546.x
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- Publication type:
- Article
Correlation of Electrophysiology with Pathology, Pathogenesis, and Anticholinesterase Therapy in Post-Polio Syndrome<sup>a</sup>.
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- Annals of the New York Academy of Sciences, 1995, v. 753, n. 1, p. 138, doi. 10.1111/j.1749-6632.1995.tb27540.x
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- Publication type:
- Article
Binding and Internalization of Neurotensin in Hybrid Cells Derived from Septal Cholinergic Neuronsa.
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- Annals of the New York Academy of Sciences, 1992, v. 668, n. 1, p. 345, doi. 10.1111/j.1749-6632.1992.tb27371.x
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- Publication type:
- Article
Diagnosis of manganism and manganese neurotoxicity: A workshop report.
- Published in:
- Medicine International (2754-3242), 2024, v. 4, n. 2, p. N.PAG, doi. 10.3892/mi.2024.135
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- Publication type:
- Article
Is creutzfeldt-Jakob disease transmitted in blood?
- Published in:
- Emerging Infectious Diseases, 1997, v. 3, n. 2, p. 155, doi. 10.3201/eid0302.970208
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- Publication type:
- Article
CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice.
- Published in:
- Alzheimer's Research & Therapy, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0461-0
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- Publication type:
- Article
Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis.
- Published in:
- Frontiers in Molecular Neuroscience, 2019, p. 1, doi. 10.3389/fnmol.2019.00262
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- Publication type:
- Article
Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral Sclerosis?
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- Frontiers in Molecular Neuroscience, 2018, p. 1, doi. 10.3389/fnmol.2018.00063
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- Publication type:
- Article
An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS.
- Published in:
- Nature Medicine, 2007, v. 13, n. 6, p. 754, doi. 10.1038/nm1559
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- Publication type:
- Article
TARGETING OF TOXIC AMYLOID-BETA OLIGOMER SPECIES BY MONOCLONAL ANTIBODY PMN310: PRECISION DRUG DESIGN FOR ALZHEIMER’S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P592, doi. 10.1016/j.jalz.2017.07.225
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- Publication type:
- Article
PROPAGATIVE TOXIC Aβ OLIGOMER SUBCLASS IDENTIFIED AND DEFINED BY SOLVENT ORIENTATION OF THE LYSINE 28 SIDE CHAIN.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1003, doi. 10.1016/j.jalz.2017.06.1394
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- Publication type:
- Article
HIGH-DENSITY LIPOPROTEINS SUPPRESS Aβ-INDUCED BRAIN MICROVASCULAR ENDOTHELIAL CELL ACTIVATION.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1302, doi. 10.1016/j.jalz.2017.06.1984
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- Publication type:
- Article
NOVEL AMYLOID-β OLIGOMER-SPECIFIC EPITOPES: A HYPOTHESIS DRIVEN APPROACH TO ALZHEIMER'S IMMUNOTHERAPEUTICS.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1191, doi. 10.1016/j.jalz.2016.07.145
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- Publication type:
- Article
THE AMYLOID-BETA (Aβ) OLIGOMER-SPECIFIC CYCLIC-SER-ASN-LYS (CSNK) TRIPEPTIDE IS HIGHLY IMMUNOGENIC AND INDUCES SUSTAINED LEVELS OF ANTI-CSNK ANTIBODIES OF THE IGG1 SUBCLASS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P834, doi. 10.1016/j.jalz.2016.06.1705
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- Publication type:
- Article
A COMPUTATIONAL METHOD TO PREDICT DISEASE-SPECIFIC EPITOPES IN Aβ, AND ITS APPLICATION TO OLIGOMER-SELECTIVE ANTIBODIES FOR ALZHEIMER’S IMMUNOTHERAPY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1148, doi. 10.1016/j.jalz.2016.07.042
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- Publication type:
- Article
An amyloid-beta oligomer epitope specific for toxic assemblages in Alzheimer’s disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P136, doi. 10.1016/j.jalz.2015.07.054
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- Publication type:
- Article
Characterization of a humanized amyloid beta oligomer monoclonal antibody (5E3) under preclinical development for passive immunotherapy of Alzheimer’s disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P275, doi. 10.1016/j.jalz.2015.07.363
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- Publication type:
- Article
Epitope-specific amyloid-β oligomer vaccination ameliorates amygdala-dependent memory deficits and inhibits region-to-region spread of plaque pathology in APP/PS1 mice.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P904, doi. 10.1016/j.jalz.2015.08.144
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- Publication type:
- Article
Mice immunized with cyclic-Ser-Asn-Lys (cSNK) peptide generate polyclonal antibodies selective for Aβ oligomers: a vaccine strategy for Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P624, doi. 10.1016/j.jalz.2014.05.1077
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- Publication type:
- Article
An immunological epitope specific for toxic oligomeric Aß in Alzheimer's disease
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- 2012
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- Publication type:
- Abstract
Amorfix Epitope Protection-Alzheimer's Disease (EP-AD) diagnostic cerebrospinal fluid test for accurate identification of Alzheimer's disease and mild cognitive impairment
- Published in:
- 2012
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- Publication type:
- Abstract
Naturally occurring human antibodies to misfolded Aβ epitope associated with Alzheimer's disease
- Published in:
- 2012
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- Publication type:
- Abstract
Development of ultra-sensitive assay for detection of aggregated beta amyloid in human CSF
- Published in:
- 2011
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- Publication type:
- Abstract
Misfolded superoxide dismutase 1 (SOD1) as a novel target for Alzheimer's disease
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- 2010
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- Publication type:
- Abstract
Early detection of β-amyloid aggregation in in vivo and in vitro models of Alzheimer's disease
- Published in:
- 2010
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- Publication type:
- Abstract
An ultrasensitive method for the detection of aggregated Beta-amyloid
- Published in:
- 2009
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- Publication type:
- Abstract
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.
- Published in:
- Nature Genetics, 2001, v. 28, n. 2, p. 131, doi. 10.1038/88842
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- Publication type:
- Article
Neuroblastoma × spinal cord (NSC) hybrid cell lines resemble developing motor neurons.
- Published in:
- Developmental Dynamics, 1992, v. 194, n. 3, p. 209, doi. 10.1002/aja.1001940306
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- Publication type:
- Article
ALS-linked misfolded SOD1 species have divergent impacts on mitochondria.
- Published in:
- Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0313-8
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- Publication type:
- Article
TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion.
- Published in:
- Scientific Reports, 2016, p. 22155, doi. 10.1038/srep22155
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- Publication type:
- Article
Intermediate CAG Repeat Expansion in the <i>ATXN2</i> Gene Is a Unique Genetic Risk Factor for ALS−A Systematic Review and Meta-Analysis of Observational Studies.
- Published in:
- PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0105534
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- Publication type:
- Article
Nanopore Analysis of Wild-Type and Mutant Prion Protein (PrP<sup>C</sup>): Single Molecule Discrimination and PrP<sup>C</sup> Kinetics.
- Published in:
- PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0054982
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- Publication type:
- Article
Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis.
- Published in:
- PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035050
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- Publication type:
- Article
Detection of Prion Protein in Urine-Derived Injectable Fertility Products by a Targeted Proteomic Approach.
- Published in:
- PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0017815
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- Publication type:
- Article