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- Title
Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review.
- Authors
Zhang, Ying; Guo, Pan; Ma, Zhe; Lu, Peng; Kebebe, Dereje; Liu, Zhidong
- Abstract
Although nanomedicine have greatly developed and human life span has been extended, we have witnessed the soared incidence of central nervous system (CNS) diseases including neurodegenerative diseases (Alzheimer's disease, Parkinson's disease), ischemic stroke, and brain tumors, which have severely damaged the quality of life and greatly increased the economic and social burdens. Moreover, partial small molecule drugs and almost all large molecule drugs (such as recombinant protein, therapeutic antibody, and nucleic acid) cannot cross the blood–brain barrier. Therefore, it is especially important to develop a drug delivery system that can effectively deliver therapeutic drugs to the central nervous system for the treatment of central nervous system diseases. Cell penetrating peptides (CPPs) provide a potential strategy for the transport of macromolecules through the blood–brain barrier. This study analyzed and summarized the progress of CPPs in CNS diseases from three aspects: CPPs, the conjugates of CPPs and drug, and CPPs modified nanoparticles to provide scientific basis for the application of CPPs for CNS diseases.
- Subjects
CELL-penetrating peptides; CENTRAL nervous system; CENTRAL nervous system diseases; HEDONIC damages; ISCHEMIC stroke
- Publication
Journal of Nanobiotechnology, 2021, Vol 19, Issue 1, p1
- ISSN
1477-3155
- Publication type
Article
- DOI
10.1186/s12951-021-01002-3