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- Title
Effectiveness and Safety of Thermal Ablation in the Treatment of Primary Hyperparathyroidism: A Multicenter Study.
- Authors
Ying Wei; Cheng-Zhong Peng; Shu-Rong Wang; Jun-Feng He; Li-Li Peng; Zhen-Long Zhao; Xiao-Jing Cao; Yan Li; Ming-An Yu; Wei, Ying; Peng, Cheng-Zhong; Wang, Shu-Rong; He, Jun-Feng; Peng, Li-Li; Zhao, Zhen-Long; Cao, Xiao-Jing; Li, Yan; Yu, Ming-An
- Abstract
<bold>Purpose: </bold>To evaluate the effectiveness and safety of thermal ablation for primary hyperparathyroidism (pHPT).<bold>Materials and Methods: </bold>From January 2015 to March 2020, data pertaining to patients who received thermal ablation for pHPT at 4 centers were retrospectively analyzed. The median follow-up duration was 18.1months (IQR: 6.5-42.2 months). A cure referred to the reestablishment of normal values of serum calcium and intact parathyroid hormone (iPTH) throughout the entire follow-up period, at least more than 6 months. The technical success, effectiveness, and safety of treatment were analyzed.<bold>Results: </bold>119 patients (mean age, 57.2 ± 16.3 years; 81 female) with 134 parathyroid nodules were enrolled. The mean maximum diameter of the parathyroid glands was 1.6 ± 0.9 cm. Ninety-six patients underwent microwave ablation (MWA), and 23 patients underwent radiofrequency ablation (RFA). The technical success rate was 98.3% and the cure rate was 89.9%. Significant differences were found in the maximum diameter between the cured patients and the patients who did not undergo ablation of the target lesions. Except the cases with pHPT nodules<0.6cm in diameter, the cure rate was 95%. There were no difference in cure rates at 6 months between the MWA and RFA (MWA vs. RFA, 90.6% vs. 87.0%; χ2=0.275, p = 0.699). The volume reduction rate of the ablation zone was 94.6% at 12 months. The complication rate was 6.7% (8/119). Except one patient with persistent voice impairment, other symptoms were spontaneously resolved within six months.<bold>Conclusion: </bold>Thermal ablation was effective and safe for pHPT.
- Subjects
PARATHYROID glands; CALCIUM metabolism; HYPERPARATHYROIDISM; SINGLE-photon emission computed tomography; RECURRENT laryngeal nerve; HIGH-intensity focused ultrasound; RESEARCH; RESEARCH methodology; CATHETER ablation; MICROWAVES; RETROSPECTIVE studies; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; RESEARCH funding
- Publication
Journal of Clinical Endocrinology & Metabolism, 2021, Vol 106, Issue 9, p2707
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgab240