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- Title
Perfluoroalkyl Substance Exposure Early In Pregnancy Was Negatively Associated With Late Pregnancy Cortisone Levels.
- Authors
Dreyer, Anja Fenger; Jensen, Richard Christian; Glintborg, Dorte; Schmedes, Anne Vibeke; Brandslund, Ivan; Nielsen, Flemming; Kyh, Henriette Boye; Jensen, Tina Kold; Andersen, Marianne Skovsager; Kyhl, Henriette Boye
- Abstract
<bold>Introduction: </bold>During pregnancy, maternal cortisol levels are increased 3-fold by the third trimester. The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD, isoforms 1 and 2) regulates the balance between cortisol and cortisone levels. Perfluoroalkyl substances (PFAS) have been reported to inhibit 11β-HSD1 and more potently 11β-HSD2, which could lead to reduced levels of cortisol and more extensively cortisone.<bold>Aim: </bold>The aim of this work is to investigate a possible effect of early pregnancy PFAS exposure on late pregnancy activity of 11β-HSD1 and 11β-HSD2 assessed by cortisol and cortisone levels in diurnal urine (dU) and blood samples.<bold>Methods: </bold>This study is part of the prospective cohort study, Odense Child Cohort (OCC). A total of 1628 pregnant women had serum (S) concentrations of 5 PFAS (perfluorooctanoic acid [PFOA], perfluorooctane sulfonic acid [PFOS], perfluorohexane sulfonic acid [PFHxS], perfluorononanoic acid [PFNA], and perfluorodecanoic acid (PFDA)) measured in the first trimester (median gestational week, GW 11). dU cortisol and cortisone (n = 344) and S-cortisol (n = 1048) were measured in the third trimester (median GW 27).<bold>Results: </bold>In multiple regression analyses, a 2-fold increase in S-PFOS was significantly associated with lower dU-cortisone (β = -9.1%, P < .05) and higher dU-cortisol/dU-cortisone (dU-C/C) (β = 9.3%, P < .05). In crude models, a doubling in PFOS, PFOA, PFHxS, and PFNA concentrations were associated with a significant increase in S-cortisol; however, these associations became insignificant after adjustment.<bold>Conclusion: </bold>Early pregnancy maternal S-PFAS were inversely associated with late pregnancy dU-cortisone, indicating reduced activity of 11β-HSD2.
- Subjects
CORTISONE; HEALTH &; Nutrition Examination Survey; RESEARCH; POLLUTANTS; THIRD trimester of pregnancy; FIRST trimester of pregnancy; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; FLUOROCARBONS; COMPARATIVE studies; OXIDOREDUCTASES; HYDROCORTISONE; LONGITUDINAL method; CHEMICAL inhibitors
- Publication
Journal of Clinical Endocrinology & Metabolism, 2020, Vol 105, Issue 8, p1
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgaa292