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- Title
Prognostic factors in cutaneous apocrine carcinoma: a single-institution retrospective study of 32 patients.
- Authors
Tsuruta, Seiji; Ogata, Dai; Namikawa, Kenjiro; Nakano, Eiji; Hiki, Kojiro; Okumura, Mao; Matsui, Yoshiyuki; Nakayama, Yuichi; Wada, Shogo; Yamazaki, Naoya
- Abstract
Background: Cutaneous apocrine carcinoma (CAC) is a rare adnexal carcinoma. Limited data exists on the demographics and overall survival (OS) of patients with CAC; thus, there is no consensus on surgical management. This study aimed to examine demographic and survival data of patients with CAC to determine optimal surgical management. Methods: A single-center retrospective cohort study was conducted at the National Cancer Center Hospital in Tokyo between 2005 and 2022. Patients with a histologically-confirmed CAC diagnosis were identified and data on patient demographics, OS, and lymph node (LN) status were gathered. Results: Thirty-two patients were included (median age, 65.5 years; male–female ratio, 15:1). The most common involvement site was the axilla (87.5%). Of the nine patients in the clinical local stage, pathological LN metastases were found in five patients. Either pathological LN or distant metastases were present in 75% of the patients at initial diagnosis. The most common initial surgical treatments included wide local excision and complete LN dissection. Across cohorts, the median OS was 39 months. Patients with ≥ 4 LN metastases had reduced recurrence-free survival and OS compared to those with ≤ 3 LN metastases (p = 0.042, p = 0.041, respectively). The OS was not remarkably different between patients who did and did not receive postoperative radiation therapy. Conclusions: Since CAC has a high rate of LN metastasis—and the number of LN metastases is a significant prognostic factor—LN evaluation should be considered for patients with CAC as initial treatment. Nonetheless, ≥ 4 LN metastases can be a poor prognostic factor for CAC.
- Subjects
PROGNOSIS; LUPUS nephritis; ADNEXAL diseases; CANCER hospitals; CARCINOMA; OVERALL survival; RETROSPECTIVE studies; RADIOTHERAPY
- Publication
International Journal of Clinical Oncology, 2023, Vol 28, Issue 12, p1690
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-023-02420-z