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- Title
Bronchial diverticula in smokers on thin-section CT.
- Authors
Sverzellati N; Ingegnoli A; Calabrò E; Randi G; La Vecchia C; Marchianò A; Kuhnigk JM; Hansell DM; Zompatori M; Pastorino U; Sverzellati, Nicola; Ingegnoli, Anna; Calabrò, Elisa; Randi, Giorgia; La Vecchia, Carlo; Marchianò, Alfonso; Kuhnigk, Jan-Martin; Hansell, David M; Zompatori, Maurizio; Pastorino, Ugo
- Abstract
The objective was to determine the prevalence of bronchial diverticula in smokers on thin-section CT and the relationship to clinical and other morphological features on CT. Thin-section CT images of 503 cigarette smokers were assessed for the profusion and location of diverticula in the major airways. The extent of the bronchial diverticula was recorded as follows: grade 0, none; grade 1, one to three diverticula; grade 2, more than three diverticula. The extent of emphysema, bronchial wall thickness, clinical features, and pulmonary function were compared in the sub-groups stratified according to the extent of bronchial diverticula. A total of 229/503 (45.5%) smokers had bronchial diverticula, with 168/503 (33.3%) and 61/503 (12.2%) having grade 1 and 2 bronchial diverticula respectively. Subjects with grade 2 bronchial diverticula were heavier smokers, reported a history of coughing more frequently, and showed more severe functional impairment, greater extent of emphysema and more severe bronchial wall thickening compared with subjects with grade 1 and those individuals without bronchial diverticula (P < 0.05). Multivariate regression analysis revealed that only bronchial wall thickness predicted the extent of the bronchial diverticula (P < 0.0001). Bronchial diverticula are a frequent finding in the major airways of smokers, and they are associated with other markers of smoking-related damage.
- Publication
European Radiology, 2010, Vol 20, Issue 1, p88
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-009-1515-2