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- Title
Identification of salivary metabolites for oral squamous cell carcinoma and oral epithelial dysplasia screening from persistent suspicious oral mucosal lesions.
- Authors
Ishikawa, Shigeo; Wong, David T. W.; Sugimoto, Masahiro; Gleber-Netto, Frederico Omar; Li, Feng; Tu, Michael; Zhang, Yong; Akin, David; Iino, Mitsuyoshi
- Abstract
Objective: To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with persistent suspicious oral mucosal lesions (PSOML). Subjects and methods: Whole unstimulated saliva samples were collected from age-, sex-, and race-matched patients who had a lesion in the oral cavity and for whom open biopsies were performed. The patients included OSCC (n = 6), OED (n = 10), and PSOML (n = 32). Hydrophilic metabolites in saliva samples were comprehensively analyzed using capillary electrophoresis mass spectrometry. To evaluate the discrimination ability of a combination of multiple markers, a multiple logistic regression (MLR) model was developed to differentiate OSCC/OED from PSOML. Results: Six metabolites were significantly different in OSCC/OED compared with PSOML. From these six metabolites, ornithine, o-hydroxybenzoate, and ribose 5-phosphate (R5P) were used to develop the MLR model, which resulted in a high value for the area under receiver operating characteristic curve (AUC 0.871, 95% confidential interval (CI) 0.760–0.982; p < 0.001) to discriminate OSCC/OED from PSOML. Conclusions: This is the first study to identify salivary metabolites that discriminate OSCC/OED from PSOML rather than from healthy controls. The profiles of salivary metabolites were significantly different between OSCC/OED and PSOML. The ability to discriminate OSCC/OED from PSOML is important for dentists who are not oral surgery specialists. These salivary metabolites showed potential for non-invasive screening to discriminate OSCC/OED from PSOML. Clinical relevance: Salivary metabolites in this study showed potential for non-invasive screening to discriminate OSCC/OED from PSOML.
- Subjects
SQUAMOUS cell carcinoma; RECEIVER operating characteristic curves; METABOLITES
- Publication
Clinical Oral Investigations, 2019, Vol 23, Issue 9, p3557
- ISSN
1432-6981
- Publication type
Article
- DOI
10.1007/s00784-018-2777-3