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- Title
Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death.
- Authors
Xiuhong Wang; Xilin Zhao; Malik, Muhammad; Drlica, Karl
- Abstract
Background: Quinolone-mediated death of Escherichia coli has been proposed to occur by two pathways. One is blocked by inhibitors of protein synthesis; the other is not. It is currently unknown how these two pathways fit with the recent observation that hydroxyl radical accumulation is associated with quinolone lethality.
- Subjects
REACTIVE oxygen species; QUINOLONE antibacterial agents; ANTIBACTERIAL agents; BACTERIA; CELL death; THIOUREA
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2010, Vol 65, Issue 3, p520
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkp486