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- Title
In vitro effects of photodynamic therapy on Aspergillus fumigatus.
- Authors
Friedberg, Joseph S.; Skema, Cynthia; Baum, Eric D.; Burdick, Jeffrey; Vinogradov, Sergei A.; Wilson, David F.; Horan, Annamarie D.; Nachamkin, Irving; Friedberg, J S; Skema, C; Baum, E D; Burdick, J; Vinogradov, S A; Wilson, D F; Horan, A D; Nachamkin, I
- Abstract
Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 x 10(1) cfu/mL with a light dose of 110 J/cm(2) and up to 2.7 x 10(6) cfu/mL with a light dose of 385 J/cm(2).
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2001, Vol 48, Issue 1, p105
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/48.1.105