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- Title
Phytochemical Profile, Antioxidant Activity and Cholinesterase Inhibition Potential of Essential Oil and Extracts of Teucrium montanum from Bosnia and Herzegovina.
- Authors
Bektasevic, Mejra; Jurin, Mladenka; Roje, Marin; Politeo, Olivera
- Abstract
Bioactive compounds from plants play an important role in slowing many neurodegenerative diseases, such as Alzheimer's disease, by inhibiting cholinesterase enzymes. Studies have shown that oxidative stress is associated with the development of Alzheimer's disease. In traditional medicine of Bosnia and Herzegovina, Teucrium montanum is used to treat numerous diseases. The chemical composition and biological activity of the essential oil (EO) and aqueous (AE) and methanol extract (ME) of this plant were studied. The chemical composition of EO was studied using GC-MS, while the composition of the extracts was studied using HPLC-DAD. Antioxidant activity was tested using the DPPH and FRAP methods. The protection of lipids and proteins from oxidation was tested using the ammonium thiocyanate and BSA oxidation methods. The ability to inhibit cholinesterases was tested by the Ellman method. The main identified EO compounds were α-cadinol, ß-selinene, δ-cadinene, epi-α-cadinol, germacrene D-4-ol, and α-pinene. The main phenolic compounds of the extracts were p-coumaric acid, ellagic acid and caffeic acid. The tested extracts showed good antioxidant radical scavenging and reducing potential and a very good ability to protect lipids and proteins from oxidation. The EO showed moderate AChE and BChE inhibition potential, while the extracts showed weak or no ability.
- Subjects
BOSNIA &; Herzegovina; ACETYLCHOLINESTERASE; ESSENTIAL oils; ALZHEIMER'S disease; CAFFEIC acid; AMMONIUM thiocyanate; ELLAGIC acid
- Publication
Separations (2297-8739), 2023, Vol 10, Issue 8, p421
- ISSN
2297-8739
- Publication type
Article
- DOI
10.3390/separations10080421