We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Contrast-enhanced ultrasonography for assessment of tubular atrophy/interstitial fibrosis in immunoglobulin A nephropathy: a preliminary clinical study.
- Authors
Yang, Wenqi; Mou, Shan; Xu, Yao; Du, Jing; Xu, Li; Li, Fenghua; Li, Hongli
- Abstract
Purpose: To investigate the potential of contrast-enhanced ultrasonography (CEUS) for evaluating the severity of tubular atrophy/interstitial fibrosis (TA/IF) in immunoglobulin A nephropathy (IgAN) patients.Materials and methods: A total of 80 patients with IgAN and 33 healthy adults were investigated. Patients were divided into three groups according to the TA/IF (T) grade of the Oxford classification: T0 (<italic>n</italic> = 28), T1 (<italic>n</italic> = 35), and T2 (<italic>n</italic> = 17). Patients and control subjects underwent conventional ultrasound (US) and CEUS. Time-intensity curves of CEUS were drawn for regions of interest located in the renal cortex and medulla using QLab software. Conventional US and CEUS quantitative parameters were analyzed. One-way analysis of variance (ANOVA), binary logistic regression, and receiver operating characteristic (ROC) curves were used.Results: There were no significant differences in renal size, cortical thickness, and medullary perfusion parameters (<italic>P</italic> > 0.05), whereas the differences in peak intensity (PI), area under the time-intensity curve (AUC) and wash-in slope (WIS) of cortical perfusion parameters between the control subjects and patients were significant (<italic>P</italic> <italic><</italic> 0.05). PI was significantly lower with the increasing degree of T (<italic>P</italic> < 0.05). PI was associated independently with the degree of T in IgAN patients (<italic>P</italic> < 0.05). ROC analysis revealed that using the optimal cutoff values of 15.38 dB for diagnosis of T0-T1 (sensitivity 83.30% and specificity 63.00%) and 14.69 dB for diagnosis of T2 (sensitivity 100.00% and specificity 66.70%), the corresponding areas under the ROC curve were found to be 0.782 and 0.952, respectively.Conclusions: CEUS can potentially be used as a noninvasive imaging marker to evaluate the severity of TA/IF in IgAN patients.
- Subjects
PULMONARY fibrosis; IMMUNOGLOBULIN A; KIDNEY cortex; KIDNEY disease diagnosis; ULTRASONIC imaging; PHYSIOLOGY; DIAGNOSIS
- Publication
Abdominal Radiology, 2018, Vol 43, Issue 6, p1423
- ISSN
2366-004X
- Publication type
Article
- DOI
10.1007/s00261-017-1301-6