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- Title
Analysis of Agreement Among Findings of Pathologists in ED01 Experiment23.
- Authors
Amato, D. A.; Lagakos, S. W.
- Abstract
The ED experiment, which involved determination of the effective dose to produce a 1% tumor rate, was carried out by the National Center for Toxicological Research (NCTR). The study involved >20,000 BALB/c female mice exposed to various doses of 2-acetylaminofluorene, a chemical known to produce bladder and liver carcinomas. After death, tissues from each animal were evaluated for the presence of several types of tumors by one of a team of NCTR pathologists. After the ED experiment was completed, the Society of Toxicology commissioned another pathologist to carry out an independent review of the bladder and liver specimens from a stratified sample of the mice. There were substantial differences in the diagnoses of both tumor types by the pathologists, but the implications for detection of a dose-response relationship are important only for liver carcinomas. [J Natl Cancer Inst 1988;80:919–925]
- Publication
JNCI: Journal of the National Cancer Institute, 1988, Vol 80, Issue 12, p919
- ISSN
0027-8874
- Publication type
Article