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- Title
Relationship Between Myocardial Galectin-3 Levels, Collagen Deposition, and Left Ventricular Function in Aging Spontaneously Hypertensive Rats.
- Authors
Huang-e Cai; Qin-yun Ruan; Li-yun Fu; Yu-peng Chen; Lei Yan; Chun-yan Huang; Zi-ling You
- Abstract
Objective: To investigate the association between myocardial galectin-3 and myocardial collagen deposition, left ventricular (LV) function in spontaneously hypertensive rats (SHR) during development of LV dysfunction. Methods: Ninety SHR and 50 WKY rats at 12 weeks old were used for experiments. During the age periods of 14-22, 24-36, 45-66, and 75-102 weeks, LV ejection fraction (LVEF) and 2D strain including LV longitudinal, radial, and circumferential strain (SL, SR, SC) were measured echocardiographically; and myocardial galectin-3, collagen volume fraction, and perivascular collagen area were evaluated histologically. Results: Myocardial galectin-3 levels in SHR increased along with collagen deposition with aging, significantly higher at 45 weeks old and were further increased at 75-102 weeks in SHR compared to WKY rats. Myocardial galectin-3 levels were positively correlated with myocardial collagen content (r = 0.70-0.80, all P < 0.01), but negatively correlated to systolic strains in all directions (r = -0.43 to -0.56, all P < 0.01) and LVEF (r = -0.62, P < 0.01). Conclusion: Progressive increases in myocardial galectin-3 and collagen deposition start at 45 weeks of age, and LV dysfunction occurs at 75 weeks of age in SHR. Myocardial galectin-3 levels are negatively correlated with cardiac dysfunction.
- Subjects
CARDIOMYOPATHIES; AGING; GALECTINS; COLLAGEN; HYPERTENSIVE crisis
- Publication
American Journal of Hypertension, 2017, Vol 30, Issue 5, p541
- ISSN
0895-7061
- Publication type
Article