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- Title
Longitudinal Changes in Late Systolic Cardiac Load and Serum NT-proBNP Levels in Healthy Middle-Aged Japanese Men.
- Authors
Hirofumi Tomiyama; Toshio Nishikimi; Chisa Matsumoto; Kazutaka Kimura; Mari Odaira; Kazuki Shiina; Akira Yamashina
- Abstract
BACKGROUND We determined whether any significant association exists between change in late systolic cardiac load with time, estimated by radial pressure waveform analysis, and development of cardiac hemodynamic stress in individuals with preserved cardiac function. METHODS Brachial-ankle pulse wave velocity, radial augmentation index (rAI), first peak of the radial pressure waveform (SP1), systolic and pulse pressure at the second peak of the radial pressure waveform (SP2 and PP2), and serum levels of N-terminal fragment B-type natriuretic peptide (NT-proBNP) were measured at the start (first examination) and at the end (second examination) of this 3-year study in healthy Japanese men (n = 1,851). RESULTS A stepwise multivariate linear regression analysis demonstrated that among the parameters of radial pressure waveform analysis and markers of arterial stiffness analyzed, only PP2 was significantly associated with serum NT-proBNP levels in study participants at both the first and second examinations. Furthermore, among the parameters analyzed, only change in PP2 was significantly correlated with the change in serum NT-proBNP levels during the study period (beta = 0.131, P< 0.001). CONCLUSIONS Sustained late systolic cardiac load might be a more significant determinant of the development of cardiac hemodynamic stress than sustained early systolic cardiac load or arterial stiffening in individuals with preserved cardiac function.
- Subjects
HEART function tests; ARTERIAL diseases; NATRIURETIC peptides; WAVE analysis; REGRESSION analysis
- Publication
American Journal of Hypertension, 2015, Vol 28, Issue 4, p452
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpu174