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- Title
Molecular Testing Turnaround Time for Non-Small Cell Lung Cancer in Routine Clinical Practice Confirms Feasibility of CAP/IASLC/AMP Guideline Recommendations: A Single-center Analysis.
- Authors
DiStasio, Marcello; Yigu Chen; Rangachari, Deepa; Costa, Daniel B.; Heher, Yael K.; VanderLaan, Paul A.; Chen, Yigu
- Abstract
<bold>Introduction: </bold>Molecular testing to identify targetable driver mutations is the standard of care for patients with advanced-stage non-small cell lung cancer. Recent guideline recommendations by the College of American Pathologists (CAP), International Association for the Study of Lung Cancer (IASLC), and Association for Molecular Pathology (AMP) established a benchmark turnaround time (TAT) target of 10 working days for results to be available to the treating oncologist and ≤ 3 days for specimens to arrive at a commercial testing laboratory if testing is not performed in-house.<bold>Methods and Materials: </bold>To provide insights regarding the pre-testing, post-testing, and testing intervals that constitute the overall TAT target, we performed a detailed workflow analysis. A total of 157 lung cancer specimens were sent out for molecular testing at a commercial vendor from a single academic medical center during the calendar year 2015.<bold>Results: </bold>Overall, 128 specimens (81.5%) met the recommended 10-working day TAT, with a median total TAT of 9 weekdays (mean ± standard deviation, 9.17 ± 4.15 days). The pre-testing interval was ≤ 3 days for 146 specimens (93.0%), and the post-testing reporting interval was < 1 day for 116 cases (73.9%). The TAT variance was not related to intrinsic specimen characteristics.<bold>Conclusion: </bold>Overall, the findings indicated that the CAP/IASLC/AMP TAT guideline recommendations are feasible for most lung cancer specimens when a streamlined system is in place.
- Subjects
DNA analysis; COLLECTION &; preservation of biological specimens; DRUG therapy; EPIDERMAL growth factor; LUNG cancer; LUNG tumors; MEDICAL protocols; PROTEIN-tyrosine kinases; PROTEINS; SYSTEM analysis; TIME; TRANSFERASES; FLUORESCENCE in situ hybridization; GENETIC testing; PILOT projects; RETROSPECTIVE studies; SEQUENCE analysis
- Publication
Clinical Lung Cancer, 2017, Vol 18, Issue 5, pe349
- ISSN
1525-7304
- Publication type
journal article
- DOI
10.1016/j.cllc.2017.03.001