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- Title
Pluripotent stem cells to hepatocytes, the journey so far (Review).
- Authors
PALAKKAN, ANWAR A.; NANDA, JYOTI; ROSS, JAMES A.
- Abstract
Over the past several years, there has been substantial progress in the field of regenerative medicine, which has enabled new possibilities for research and clinical application. For example, there are ongoing efforts directed at generating functional hepatocytes from adult-derived pluripotent cells for toxicity screening, generating disease models or, in the longer term, for the treatment of liver failure. In the present review, the authors summarise recent developments in regenerative medicine and pluripotent stem cells, the methods and tissues used for reprogramming and the differentiation of induced pluripotent stem cells (iPSCs) into hepatocyte-like cells. In addition, the hepatic disease models developed using iPSC technologies are discussed, as well as the potential for gene editing.
- Subjects
LIVER failure; PLURIPOTENT stem cells; LIVER cells; REGENERATIVE medicine; GENOME editing; THERAPEUTICS
- Publication
Biomedical Reports, 2017, Vol 6, Issue 4, p367
- ISSN
2049-9434
- Publication type
Article
- DOI
10.3892/br.2017.867