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- Title
Y-box binding protein expression in thyroid neoplasms: Its linkage with anaplastic transformation.
- Authors
Ito, Yasuhiro; Yoshida, Hiroshi; Shibahara, Kotaro; Uruno, Takashi; Nakano, Keiichi; Takamura, Yuuki; Miya, Akihiro; Kobayashi, Kaoru; Yokozawa, Tamotsu; Matsuzuka, Fumio; Uchimi, Takeshi; Kuwano, Michihiko; Miyoshi, Eiji; Matsuura, Nariaki; Kuma, Kanji; Miyauchi, Akira
- Abstract
Recent studies have demonstrated that Y-box binding protein (YB-1) regulates the transcription of genes linked to carcinoma progression. In this study, we investigated the expression of this protein in thyroid neoplasms to elucidate its significance. The expression of YB-1 was immunohistochemically investigated using the monoclonal antibody for various thyroid neoplasms. Normal follicles did not overexpress YB-1, and only moderate overexpression of YB-1 was observed in some follicular tumors and papillary carcinoma, especially those of a larger size. In contrast, 92.9% of anaplastic carcinoma strongly overexpressed YB-1. YB-1 immunoreactivity was seen in both cytoplasms and cell nuclei, but the former was more predominant. These findings suggest that YB-1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma.
- Subjects
THYROID cancer; IMMUNOHISTOCHEMISTRY; MONOCLONAL antibodies; CARRIER proteins
- Publication
Pathology International, 2003, Vol 53, Issue 7, p429
- ISSN
1320-5463
- Publication type
Article
- DOI
10.1046/j.1440-1827.2003.01494.x