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- Title
Hepatitis C: clinical and biological features related to different forms of cocaine use.
- Authors
Schuch-Goi, Silvia Bassani; Scherer, Juliana Nichterwitz; Kessler, Felix Henrique Paim; Sordi, Anne Orgler; Pechansky, Flavio; von Diemen, Lisia
- Abstract
Introduction: Hepatitis C virus (HCV) infection is related with several liver diseases such as cirrhosis and hepatocellular carcinomas, leading to more than 0.5 million deaths every year and to a great global burden. It is known that injection drug users show a high prevalence of HCV infection, being considered a risk group for this disease. Cocaine users seem to be in greater risk than other drug users, and several hypotheses for this association are being studied. Aim: To review data on HCV infection in cocaine users, taking into consideration the relevance of the different routes of drug administration and other risk behaviors. Methods: This was a narrative review performed in the main scientific databases. Results and conclusion: Data suggest that cocaine use could be associated with HCV infection due to the specificities of cocaine consumption pattern, even in those subjects who do not inject drugs, in addition to other risky behaviors, such as tattooing and unprotected sex. Injectable cocaine users seem to be more susceptible to contamination than users who do not inject drugs. However, evidence is pointing to the possibility of infection by sharing drug paraphernalia other than syringes. Moreover, specific immune system impairments caused by cocaine use are also being linked with HCV infection susceptibility, persistence and increased pathological effects.
- Subjects
HEPATITIS C treatment; COCAINE abuse; LIVER diseases; CIRRHOSIS of the liver; DRUG administration; DISEASE susceptibility
- Publication
Trends in Psychiatry & Psychotherapy, 2017, Vol 39, Issue 4, p285
- ISSN
2237-6089
- Publication type
Article
- DOI
10.1590/2237-6089-2016-0076