We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Anti-.
- Authors
Granito, A.; Zauli, D.; Muratori, P.; Muratori, L.; Grassi, A.; Bortolotti, R.; Petrolini, N.; Veronesi, L.; Gionchetti, P.; Bianchi, F. B.; Volta, U.
- Abstract
: Anti-Saccharomyces cerevisiaeand perinuclear anti-neutrophil cytoplasmic autoantibodies are markers of Crohn's disease and ulcerative colitis respectively.: To determine the prevalence of anti-S. cerevisiaeand perinuclear anti-neutrophil cytoplasmic autoantibodies in a large series of coeliac disease patients before and after gluten free diet, and to correlate anti-S. cerevisiae-positivity with intestinal mucosal damage.: One hundred and five consecutive coeliac disease patients and 141 controls (22 ulcerative colitis, 24 Crohn's disease, 30 primary sclerosing cholangitis, 15 postenteritis syndrome, 50 blood donors) were tested for anti-S. cerevisiaeby enzyme-linked immunosorbent assay and for perinuclear anti-neutrophil cytoplasmic autoantibodies by indirect immunofluorescence.: In coeliac disease anti-S. cerevisiae(immunoglobulin G and/or immunoglobulin A) were slightly less frequent (59%) than in Crohn's disease (75%,P = 0.16) and significantly more frequent than in ulcerative colitis (27%), primary sclerosing cholangitis (30%), postenteritis syndrome (26%) and blood donors (4%) (P = 0.009,P = 0.0002,P = 0.025,P < 0.0001). No correlation was found between anti-S. cerevisiaeand degree of mucosal damage. Perinuclear anti-neutrophil cytoplasmic autoantibodies were detected only in one coeliac. After gluten free diet the disappearance of anti-S. cerevisiae-immunoglobulin A (93%) was more frequent than that of immunoglobulin G (17%,P = 0.0001); perinuclear anti-neutrophil cytoplasmic autoantibodies disappeared in the only coeliac positive at diagnosis.: More than half of untreated coeliacs are anti-S. cerevisiae-positive irrespective of the severity of mucosal damage. Differently from immunoglobulin A, anti-S. cerevisiae-immunoglobulin G persisted in more than 80% after gluten free diet. The high prevalence of anti-S. cerevisiaein coeliac disease suggests that they may be the effect of a non-specific immune response in course of chronic small bowel disease.
- Subjects
IMMUNOGLOBULINS; CELIAC disease; AUTOIMMUNITY; DIARRHEA; INFLAMMATORY bowel diseases; ULCERATIVE colitis
- Publication
Alimentary Pharmacology & Therapeutics, 2005, Vol 21, Issue 7, p881
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2005.02417.x