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- Title
Successful tandem (autologous-cord blood) SCT in advanced neuroblastomas with highly amplified MYCN.
- Authors
Goi, K.; Inukai, T.; Honna, H.; Akahane, K.; Hirose, K.; Kuroda, I.; Hasuda, N.; Koshizuka, K.; Takano, K.; Sugita, K
- Abstract
Although autologous tandem hematopoietic SCT has improved the prognosis of patients with advanced high-risk neuroblastoma, the results remain unsatisfactory. In an attempt to induce the graft-versus-tumor effect, we performed autologous PBSCT followed by allogeneic cord blood transplantation in three consecutive advanced neuroblastoma cases with marked BM infiltration and high MYCN amplification. Severe acute complications did not occur in any patient and they have maintained disease-free survival for 37-60 months. This strategy appears to be feasible and effective for the treatment of extremely high-risk neuroblastoma cases.
- Subjects
HEMATOPOIETIC stem cell transplantation; NEUROBLASTOMA; CORD blood transplantation; AUTOTRANSFUSION of blood; GRAFT versus host disease; PROGNOSIS
- Publication
Bone Marrow Transplantation, 2011, Vol 46, Issue 6, p835
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/bmt.2010.191